%0 Journal Article
%T 滑膜肉瘤相关发病机制的研究进展
%A 冯建刚
%A 贾志峰
%A 赵亚恒
%A 郑丽华
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.07.016
%X 摘要 滑膜肉瘤（synovial sarcoma, SS）是源于关节、滑膜及腱鞘滑膜的软组织恶性肿瘤，因其在关节周围的经典表现而得名。滑膜肉瘤可发生在身体任何部位，但以四肢近关节处多见。95%的SS以t（X;18）（p11.2-q11.2）染色体易位为特点，形成融合基因SYT-SSX，从而通过Wnt/β-catenin、PcG和ERK等信号通路促进SS细胞发生。另外，TGF-β1、Smad、Snail和Slug通过EMT途径也参与SS的发生发展。除此之外SS的发病还涉及有许多因子改变，如Twist1、Bmi1等。近年来研究表明上述因素均和SS的发病机制有关。本文将对这些因素在SS发生发展方面的作用作一概述
%K 滑膜肉瘤
%K 发病机制
%K SYT-SSX
%K 上皮-间质转化
%K Relationship Between Human Papillomavirus and miRNA Expression
%K Advances on Etiology of Uterine Leiomyosarcoma
%K Advances of Aberrant miRNAs Expression in Multiple Myeloma
%K Progress on Osteosarcoma Pathogenesis
%K Expression and Clinical Signifi cance of E-cadherin and N-cadherin in Nasopharyngeal#br# Carcinoma
%K Effect of Hypoxia and HIF-1α on Epithelial-mesenchymal Transition
%K Invasion and Proliferation in Colorectal Cancer
%K Clinicopathologic Features and Epidermal Growth Factor Receptor Mutations Associated with Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer
%K The Mechanism of Prolactinomas Induced by Estrogen in Rats
%K A Study of the Mechanism and Treatment Strategics in Malignant Tumor Complicated by Deep Venous Thrombosis
%K PRJMARY MALIGNANT TUMORS INVOLVED THE CENTAL NERVOUS SYSTFM
%U http://www.zlfzyj.com/CN/abstract/abstract8545.shtml