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-  2016 

干细胞因子Nanog在肿瘤中的研究进展

DOI: 10.3971/j.issn.1000-8578.2016.04.012

Keywords: Nanog,干细胞因子,肿瘤,分子标志物,Perioperative Security Evaluation of Intra-operative Radiotherapy for Recurrent Bone and Soft Tissue Sarcomas Around Pelvis,Role of CD147 and Its Ligand CypA in Hepatoma Carcinoma Hepa1-6 Cells Escaping from Immune Surveillance of T cells,Pathological and Biological Mechanisms of Radiation-induced Heart Disease,Research Progress of FGFR4 Targeted Anti-tumor Drug,NDRG2 Inhibits Migration of Breast Cancer Cells Through Upregulating PTEN Expression,Preliminary Investigation About Hematokrit Forecast of Chemotherapy Tolerance of Lung Cancer Patients,Progress on Relationship Between Posttranslational Modification Enzymes of Collagen and Tumor,Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility,Progress on FOXP3 Expression in Breast Cancer Cells,Comparison of Application Value of Contrast Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging in Differential Diagnosis of Benign and Malignant Renal Tumors,Effect of PTTG1 Expression on Invasion and Migration of Colon Cancer Cell SW480 and Its Possible Mechanism,Death of Malignant Tumors and Potential Years of Life Lost Among Residents in Shandong Province, 2010-2012,Cancer Incidence and Mortality in Cancer Registries in Hubei Province, 2012,Liver Cancer Incidence and Mortality Rates During Last 40 Years in Hebei Province,Molecular Classification of Common Solid Cancers

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Abstract:

摘要 Nanog是维持胚胎干细胞自我更新和多能性的关键转录因子。Nanog在分化的细胞中表达逐渐降低或缺失。研究发现肿瘤细胞中Nanog异常激活,并且与肿瘤发生、发展和转移密切相关。Nanog通过调控肿瘤细胞增殖、迁移和侵袭、肿瘤干性以及肿瘤免疫逃逸等多种机制参与肿瘤生长、转移和耐药。临床研究证据提示Nanog在肿瘤患者中异常高表达,可作为预后评估的独立指标。本文就Nanog在肿瘤中的作用、分子机制和临床应用的研究进展作一综述

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