%0 Journal Article
%T 干细胞因子Nanog在肿瘤中的研究进展
%A 刘叶
%A 张徐
%A 徐梦
%A 许文荣
%A 钱晖
%A 顾笑笑
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.04.012
%X 摘要 Nanog是维持胚胎干细胞自我更新和多能性的关键转录因子。Nanog在分化的细胞中表达逐渐降低或缺失。研究发现肿瘤细胞中Nanog异常激活，并且与肿瘤发生、发展和转移密切相关。Nanog通过调控肿瘤细胞增殖、迁移和侵袭、肿瘤干性以及肿瘤免疫逃逸等多种机制参与肿瘤生长、转移和耐药。临床研究证据提示Nanog在肿瘤患者中异常高表达，可作为预后评估的独立指标。本文就Nanog在肿瘤中的作用、分子机制和临床应用的研究进展作一综述
%K Nanog
%K 干细胞因子
%K 肿瘤
%K 分子标志物
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%U http://www.zlfzyj.com/CN/abstract/abstract8733.shtml