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DOI: 10.3971/j.issn.1000-8578.2015.02.022
Keywords: HOXB7,肿瘤,转录因子,信号通路,Perioperative Security Evaluation of Intra-operative Radiotherapy for Recurrent Bone and Soft Tissue Sarcomas Around Pelvis,Role of CD147 and Its Ligand CypA in Hepatoma Carcinoma Hepa1-6 Cells Escaping from Immune Surveillance of T cells,Pathological and Biological Mechanisms of Radiation-induced Heart Disease,Research Progress of FGFR4 Targeted Anti-tumor Drug,NDRG2 Inhibits Migration of Breast Cancer Cells Through Upregulating PTEN Expression,Preliminary Investigation About Hematokrit Forecast of Chemotherapy Tolerance of Lung Cancer Patients,Progress on Relationship Between Posttranslational Modification Enzymes of Collagen and Tumor,Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility,Progress on FOXP3 Expression in Breast Cancer Cells,Comparison of Application Value of Contrast Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging in Differential Diagnosis of Benign and Malignant Renal Tumors,Effects of GSTP1 on Proliferation and Invasion of Human HepG2 Cells,Effect of Down-regulating KLF8 Expression by siRNA on EMT in Nasopharyngeal Carcinoma Cells,Effect of PTTG1 Expression on Invasion and Migration of Colon Cancer Cell SW480 and Its Possible Mechanism,Death of Malignant Tumors and Potential Years of Life Lost Among Residents in Shandong Province, 2010-2012,Cancer Incidence and Mortality in Cancer Registries in Hubei Province, 2012
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摘要 转录因子HOXB7在多种肿瘤组织中高表达，且与肿瘤分期、预后密切相关。研究表明，HOXB7不仅参与调控细胞增殖和凋亡，在肿瘤转移过程中也发挥重要作用。多个信号转导通路可以调控HOXB7的表达与活化，同时HOXB7也可影响通路中多个重因子，其在肿瘤发生发展中发挥重 要作用，可成为肿瘤治疗的潜在靶点
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