MR表观扩散系数预测鼻咽癌放疗敏感度及相关因素分析
DOI: 10.3971/j.issn.1000-8578.2015.12.011
Keywords: 扩散加权成像,表观扩散系数,鼻咽肿瘤,放射治疗,敏感度,Relationship Between NF-κB and Epithelial-to-mesenchymal Transition of Radiationinduced Human Esophageal Carcinoma Cells,Effect of Gene Silencing of RNF2 on Radiosensitivity of Esophageal Carcinoma Cells,Effect of RNA Interference Decreasing MSI1 Expression on Chemosensitivity of Human Glioma Cells,Regulatory Mechanisms and Clinical Application Perspectives of NF-κB in Tumor Radiosensitivity,GDF11 is Involved in Human Hepatic Carcinoma Cells SMMC-7721 Proliferation and Sensitivity to DDP,Effect of Intensity Modulated Radiotherapy Combined with Hormonal Therapy on Fatigue in Patients with Locally Advanced Prostate Cancer,Prognosis of Clinical Stage ⅢA(N2) Non-small Cell Lung Cancer Patients Received Radiotherapy,Effect of siRNA-mediated notch1 Gene Silencing on Apoptosis and Radiosensitivity of Glioma Cell Line U87-EGFRvⅢ,Application of Helical Tomotherapy in Treatment for Head and Neck Cancer,FAT10-induced Autophagy Regulates Radiosensitivity of Hepatocellular Carcinoma Cells,Advances of Dose-painting Radiotherapy,Application Progress of Helical Tomotherapy in Central Nervous System Neoplasms,miR-200c Enhances Sensitivity of Lung Cancer Cell A549 to Paclitaxel and Gefitinib and Related Mechanism,Effect of Tumor Length, Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients,Comparison of 6th and 7th Editions of AJCC/UICC TNM Staging for Esophageal Cancer#br# Patients Received Radiotherapy
Abstract:
摘要 目的 探讨利用MR扩散加权成像的表观扩散系数（ADC值）预测鼻咽癌放疗敏感度的可行性。 方法 97例鼻咽癌患者在放疗前行MR扩散加权成像检查，并测量肿瘤灶ADC值。根据放射治疗后的效果将鼻咽癌患者按放疗敏感度进行分组，放疗敏感组74例、放疗抗拒组23例。分析放疗敏感度与ADC值、病理分型、T分期的相互关系。 结果 放疗敏感组的ADC值为（0.792±0.121）×10-3mm2/s，其中非角化型分化型癌23例，非角化型未分化癌51例，T1期10例，T2期33例，T3期22例，T4期9例。放疗抗拒组的ADC值为（0.730±0.104）×10-3 mm2/s，其中非角化型分化型癌8例，非角化型未分化癌15例，T1期3例，T2期4例，T3期7例，T4期9例。两组间在ADC值、T分期方面差异均有统计学意义（t=2.199, P=0.030; χ 2=10.287,P=0.016），在病理分型方面差异无统计学意义（χ 2=0.111, P=0.740）。各T分期的ADC值整体上差异有统计学意义（F=8.597, P=0.000），随着T分期的增高，ADC值呈现下降趋势。ADC值、T分期预测鼻咽癌放疗敏感度的ROC曲线下的面积（Az）值分别为0.657、0.661。当ADC值取0.737×10-3 mm2/s为诊断阈值时，其诊断价值最大，敏感度为68.9%，特异性为69.6%。结论 ADC值可以预测鼻咽癌放疗敏感度，其价值接近于Ｔ分期，最佳诊断阈值为0.737×10-3 mm2/s
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