%0 Journal Article
%T MR表观扩散系数预测鼻咽癌放疗敏感度及相关因素分析
%A 彭俊琴
%A 李伟
%A 李建生
%A 汤日杰
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.12.011
%X 摘要 目的 探讨利用MR扩散加权成像的表观扩散系数（ADC值）预测鼻咽癌放疗敏感度的可行性。 方法 97例鼻咽癌患者在放疗前行MR扩散加权成像检查，并测量肿瘤灶ADC值。根据放射治疗后的效果将鼻咽癌患者按放疗敏感度进行分组，放疗敏感组74例、放疗抗拒组23例。分析放疗敏感度与ADC值、病理分型、T分期的相互关系。 结果 放疗敏感组的ADC值为（0.792±0.121）×10-3mm2/s，其中非角化型分化型癌23例，非角化型未分化癌51例，T1期10例，T2期33例，T3期22例，T4期9例。放疗抗拒组的ADC值为（0.730±0.104）×10-3 mm2/s，其中非角化型分化型癌8例，非角化型未分化癌15例，T1期3例，T2期4例，T3期7例，T4期9例。两组间在ADC值、T分期方面差异均有统计学意义（t=2.199, P=0.030; χ 2=10.287,P=0.016），在病理分型方面差异无统计学意义（χ 2=0.111, P=0.740）。各T分期的ADC值整体上差异有统计学意义（F=8.597, P=0.000），随着T分期的增高，ADC值呈现下降趋势。ADC值、T分期预测鼻咽癌放疗敏感度的ROC曲线下的面积（Az）值分别为0.657、0.661。当ADC值取0.737×10-3 mm2/s为诊断阈值时，其诊断价值最大，敏感度为68.9%，特异性为69.6%。结论 ADC值可以预测鼻咽癌放疗敏感度，其价值接近于Ｔ分期，最佳诊断阈值为0.737×10-3 mm2/s
%K 扩散加权成像
%K 表观扩散系数
%K 鼻咽肿瘤
%K 放射治疗
%K 敏感度
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%U http://www.zlfzyj.com/CN/abstract/abstract8659.shtml