ASPP调控肿瘤细胞凋亡作用的研究进展
DOI: 10.3971/j.issn.1000-8578.2016.05.019
Keywords: ASPP家族,肿瘤发生,p53,凋亡,Effects of RNAi Silencing GTPBP4 Gene on Proliferation and Apoptosis of Colon Cancer RKO Cells,Effect of Thyroid Hormone Receptor βΔ on Proliferation and Apoptosis of Rat Breast Cancer Cells SHZ-88,siRNA-mediated Inhibition of MTH1 Gene Expression Promotes Apoptosis and Reduces Migration of Hepatocellular Carcinoma HepG2 Cells,Effect of SAHA on Proliferation and Apoptosis of Breast Cancer Cells MDA-MB-435 and Related Mechanism,Effects of FEN1 Overexpression on Biological Behaviors of Hepatocellular Carcinoma Cells and Prognosis of Patients,Effect of GANT61 on Apoptosis of Esophageal Squamous Carcinoma Cells and Its Mechanism,Progress of Relationships of Calprotectin with Tumours,Experimental Investigation on Apoptosis of Cervical Cancer Cells Promoted by NF-κB Decoy ODN,Cryptotanshinone Promotes Apoptosis of A549 Cells via Inhibiting Cap-dependent mRNA Translation,Effect of Terpinen-4-ol on Proliferation and Apoptosis of Human Multiple Myeloma Cells U266,Effect of Long Non-coding RNA LOC100294362 on Proliferation and Invasion of Breast Cancer Cells,Periplocin Extracted from Cortex Periplocae(CPP) Induced Apoptosis of Gastric Cancer Cells MGC-803 Through Lysosomal Pathway,Effect of AT Motif Binding Factor 1 on Proliferation and Invasion of Colorectal Carcinoma Cell Line LOVO,Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis,Valuation of SUVmax, Ki-67, p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients
Abstract:
摘要 p53基因作为机体重要的凋亡调控因子，在受到致癌因素刺激后可诱导细胞出现细胞周期阻滞或凋亡。细胞凋亡或程序性死亡过程受到干扰或破坏时，可引起细胞异常增殖及恶性转化而导致肿瘤的发生。近期研究发现了一类新的p53相互作用蛋白ASPP家族，它们能够特异性调控p53家族分子的细胞凋亡诱导功能，揭示了p53诱导细胞凋亡的新机制，为脊柱肿瘤发生和靶向治疗研究提供了新思路。本文针对ASPP基因结构特点、调控肿瘤细胞凋亡作用和其临床意义等方面的研究进展进行综述
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