%0 Journal Article
%T ASPP调控肿瘤细胞凋亡作用的研究进展
%A 刘晓光
%A 祝斌
%A 马云龙
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.05.019
%X 摘要 p53基因作为机体重要的凋亡调控因子，在受到致癌因素刺激后可诱导细胞出现细胞周期阻滞或凋亡。细胞凋亡或程序性死亡过程受到干扰或破坏时，可引起细胞异常增殖及恶性转化而导致肿瘤的发生。近期研究发现了一类新的p53相互作用蛋白ASPP家族，它们能够特异性调控p53家族分子的细胞凋亡诱导功能，揭示了p53诱导细胞凋亡的新机制，为脊柱肿瘤发生和靶向治疗研究提供了新思路。本文针对ASPP基因结构特点、调控肿瘤细胞凋亡作用和其临床意义等方面的研究进展进行综述
%K ASPP家族
%K 肿瘤发生
%K p53
%K 凋亡
%K Effects of RNAi Silencing GTPBP4 Gene on Proliferation and Apoptosis of Colon Cancer RKO Cells
%K Effect of Thyroid Hormone Receptor βΔ on Proliferation and Apoptosis of Rat Breast Cancer Cells SHZ-88
%K siRNA-mediated Inhibition of MTH1 Gene Expression Promotes Apoptosis and Reduces Migration of Hepatocellular Carcinoma HepG2 Cells
%K Effect of SAHA on Proliferation and Apoptosis of Breast Cancer Cells MDA-MB-435 and Related Mechanism
%K Effects of FEN1 Overexpression on Biological Behaviors of Hepatocellular Carcinoma Cells and Prognosis of Patients
%K Effect of GANT61 on Apoptosis of Esophageal Squamous Carcinoma Cells and Its Mechanism
%K Progress of Relationships of Calprotectin with Tumours
%K Experimental Investigation on Apoptosis of Cervical Cancer Cells Promoted by NF-κB Decoy ODN
%K Cryptotanshinone Promotes Apoptosis of A549 Cells via Inhibiting Cap-dependent mRNA Translation
%K Effect of Terpinen-4-ol on Proliferation and Apoptosis of Human Multiple Myeloma Cells U266
%K Effect of Long Non-coding RNA LOC100294362 on Proliferation and Invasion of Breast Cancer Cells
%K Periplocin Extracted from Cortex Periplocae(CPP) Induced Apoptosis of Gastric Cancer Cells MGC-803 Through Lysosomal Pathway
%K Effect of AT Motif Binding Factor 1 on Proliferation and Invasion of Colorectal Carcinoma Cell Line LOVO
%K Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis
%K Valuation of SUVmax
%K Ki-67
%K p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients
%U http://www.zlfzyj.com/CN/abstract/abstract8757.shtml