错配修复系统hMutS、hMutL的变异与结直肠癌的相关性研究进展
DOI: 10.3971/j.issn.1000-8578.2016.07.017
Keywords: A Comparison Between Immunohistochemistry and PCR Method,Effect of Apolipoprotein E on Invasion and Migration of Colorectal Cancer Cells,MicroRNA-31 Expression in Colorectal Cancer and Bioinformatic Analysis of Its Predicted Target Genes,Individualized Treatment for Advanced Colorectal Cancer Patients Based on Molecular Characteristics,Serum Peptidome Patterns of Colorectal Cancer Based on Magnetic Bead Separation and Mass-spectrometry Technique,Role of Cancer-associated Fibroblasts in Occurrence and Development of Colorectal Cancer,Role of Hepatocyte Growth Factor Receptor c-met Regulating Epithelial-mesenchymal Transition in Metastasis of Colorectal Cancer,Virulence Gene Mutation in Seven Kindreds of Lynch Syndrome in Yunnan Province,Meta-analysis of Relationship Between Blood 25-hydroxyvitamin D Level and Colorectal Cancer,Epidemiological Trends of Colorectal Cancer,Expression of KLF17 Protein in Human Colorectal Cancer Tissue and Its Correlation with Prognosis
Abstract:
摘要 DNA错配修复系统（mismatch repair system，MMR）是重要的复制后修复机制，修复各种类型的碱基错配和插入/缺失环。hMutS、hMutL是MMR中重要的两个子系统，它们的功能缺陷与多种肿瘤，尤其结直肠癌密切相关。hMutS、hMutL系统关键基因SNPs、启动子甲基化水平的变化，都会直接或间接影响MMR的功能，以及由此引起微卫星不稳定性增加，进而影响结直肠癌的发生、发展和预后。本文主要从hMutS、hMutL系统关键基因的SNPs、启动子甲基化和微卫星不稳定三个方面综述了hMutS、hMutL系统关键基因变异与结直肠癌相关性研究的进展
Full-Text
