%0 Journal Article
%T 错配修复系统hMutS、hMutL的变异与结直肠癌的相关性研究进展
%A 倪娟
%A 吴暇玉
%A 周滔
%A 梁子卿
%A 段典榕
%A 汪旭
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.07.017
%X 摘要 DNA错配修复系统（mismatch repair system，MMR）是重要的复制后修复机制，修复各种类型的碱基错配和插入/缺失环。hMutS、hMutL是MMR中重要的两个子系统，它们的功能缺陷与多种肿瘤，尤其结直肠癌密切相关。hMutS、hMutL系统关键基因SNPs、启动子甲基化水平的变化，都会直接或间接影响MMR的功能，以及由此引起微卫星不稳定性增加，进而影响结直肠癌的发生、发展和预后。本文主要从hMutS、hMutL系统关键基因的SNPs、启动子甲基化和微卫星不稳定三个方面综述了hMutS、hMutL系统关键基因变异与结直肠癌相关性研究的进展
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%U http://www.zlfzyj.com/CN/abstract/abstract8802.shtml