MicroRNA靶基因3’端非翻译区单核苷酸多态性与肺癌关联的功能性研究进展
DOI: 10.3971/j.issn.1000-8578.2015.05.020
Keywords: A Meta-analysis,Effect of Rap2a on Invasion and Metastasis of Lung Cancer Cells and Its Related Mechanism,Immune Killing Effect of Silencing TIPE2 Expression on T Lymphocytes Against Lung Adenocarcinoma Cells LA795,NSCLC的疫苗治疗研究进展,Experiment of Different Administration Sequences of Apatinib and Paclitaxel on Lung Cancer,Cryptotanshinone Promotes Apoptosis of A549 Cells via Inhibiting Cap-dependent mRNA Translation,Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer,Effect of Vascular Endothelial Cadherin on Invasion and Metastasis of Non-small Cell Lung Cancer Cells and Related Mechanism,Advances of FGF/FGFR Signaling Pathway in Targeted Therapy for Squamous Cell Lung Cancer,Sulforaphane Suppressed Proliferation of Lung Cancer Stem Cells in vitro,Expressions of MMP-7 mRNA, sMICA, VEGF in Peripheral Blood of Lung Cancer Patients and Their Relationships with Invasion and Metastasis
Abstract:
摘要 肺癌位居目前世界恶性肿瘤死因第一位，其发生发展是遗传易感性和环境危险因素相互作用的结果。近年来的流行病学及分子生物学研究发现，存在于肺癌相关microRNA靶基因3’端非翻译区上的SNPs与肺癌的易感性及预后存在关联，可能在肺癌的发生发展中发挥一定的生物学功能。本文对这些SNPs在肺癌的易感性及预后中的功能研究进展作一简要综述，旨在为肺癌等恶性肿瘤的研究、诊断、治疗和预防提供参考
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