%0 Journal Article
%T MicroRNA靶基因3’端非翻译区单核苷酸多态性与肺癌关联的功能性研究进展
%A 林明艳
%A 蔡琳
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.05.020
%X 摘要 肺癌位居目前世界恶性肿瘤死因第一位，其发生发展是遗传易感性和环境危险因素相互作用的结果。近年来的流行病学及分子生物学研究发现，存在于肺癌相关microRNA靶基因3’端非翻译区上的SNPs与肺癌的易感性及预后存在关联，可能在肺癌的发生发展中发挥一定的生物学功能。本文对这些SNPs在肺癌的易感性及预后中的功能研究进展作一简要综述，旨在为肺癌等恶性肿瘤的研究、诊断、治疗和预防提供参考
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%U http://www.zlfzyj.com/CN/abstract/abstract8500.shtml