丁丙诺啡与吗啡联合用于大鼠骨癌痛治疗的疼痛行为学观察
DOI: 10.3971/j.issn.1000-8578.2015.05.009
Keywords: 吗啡,丁丙诺啡,联合用药,耐受,骨癌痛,Preliminary Investigation About Hematokrit Forecast of Chemotherapy Tolerance of Lung Cancer Patients,Influence of Drug Combinations on High-dose Methotrexate-induced Nephrotoxicity and Blood Concentrations of Childhood Acute Lymphoblastic Leukemia,Ionizing Radiation Overcomes Gefitinib Resistance of Non-small Cell Lung Cancer Cell Line H1975 in vitro,Mechanism of Hypoxia-inducible Factor-1α Inducing Drug Resistance to Oxaliplatin in Hepatic Carcinoma,Lidamycin Enhances Sensitivity of Multiple Myeloma to Bortezomid by Modulating Expression of Mitogen-activated Protein Kinases,Clinical Observation of Continuous Intravenous Morphine Pumping in Patients with Refractory Cancer Pain,Dose Escalation of Topotecan Combined Whole Brain Radiotherapy for Brain Metastasis of Lung Cancer,Expression ofTLRs in S180 Osteosarcoma andRelationship between TLRs and Tumor Tolerance,Analysis on Clinical Efficacy of Gemcitabine Combined with Capecitabine for Patients with Anthracycline and Taxane-refractory Metastatic Breast Cancer,Comparison of Morphine Sustained Release Tablets between Rectal Administration and O2 ral Administration in Treatment of Cancer Pain,Tolerabil ity of Oxal ipltin2based Adjuvant Chemotherapy in Colorectal Cancer Patients,Effect of Mifepristone on Proliferation and Expression of Non-classical Human Leucocyte Antigen Class Ⅰ Molecules in Choriocarcinoma Cell Line
Abstract:
摘要 目的 观察不同剂量的丁丙诺啡与吗啡联合应用于大鼠骨癌痛的疼痛行为学变化，为临床合理应用阿片类药物治疗癌痛提供参考。方法 选择成年雌性Wistar大鼠进行实验，应用Walker256细胞建立骨癌痛模型，将骨癌痛大鼠分为5组，每组8只，分别于每日7:00 am和19:00 pm进行皮下注射，连续7日。吗啡组（M组）：吗啡10 mg/kg；吗啡+丁丙诺啡1组（MB1组）：吗啡10 mg/kg+丁丙诺啡20μg/kg；吗啡+丁丙诺啡2组（MB2组）：吗啡10 mg/kg+丁丙诺啡40 μg/kg；吗啡+丁丙诺啡3组（MB3组）：吗啡10 mg/kg+丁丙诺啡60 μg/kg；假手术组（Sham组）：皮下注射0.9%氯化钠溶液1 ml。全部大鼠于建模第15天开始，每日给药前30 min、给药后30 min进行疼痛行为学测定，包括甩尾实验、机械性痛觉敏感度测定、热痛觉敏感度测定。结果 给药7天内，机械痛阈和甩尾实验测定抗伤害痛阈结果显示，各MB组与M组给药后痛阈差异均无统计学意义；热痛阈结果显示：MB2组出现明显的热痛阈下降较M组晚（第6天vs.第5天）。结论 骨癌痛大鼠癌痛治疗时，丁丙诺啡与吗啡联合应用镇痛作用相似且可延缓吗啡的耐受发生
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