%0 Journal Article
%T 丁丙诺啡与吗啡联合用于大鼠骨癌痛治疗的疼痛行为学观察
%A 周亮
%A 孙亮
%A 孙莉
%A 武林鑫
%A 董彦鹏
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.05.009
%X 摘要 目的 观察不同剂量的丁丙诺啡与吗啡联合应用于大鼠骨癌痛的疼痛行为学变化，为临床合理应用阿片类药物治疗癌痛提供参考。方法 选择成年雌性Wistar大鼠进行实验，应用Walker256细胞建立骨癌痛模型，将骨癌痛大鼠分为5组，每组8只，分别于每日7:00 am和19:00 pm进行皮下注射，连续7日。吗啡组（M组）：吗啡10 mg/kg；吗啡+丁丙诺啡1组（MB1组）：吗啡10 mg/kg+丁丙诺啡20μg/kg；吗啡+丁丙诺啡2组（MB2组）：吗啡10 mg/kg+丁丙诺啡40 μg/kg；吗啡+丁丙诺啡3组（MB3组）：吗啡10 mg/kg+丁丙诺啡60 μg/kg；假手术组（Sham组）：皮下注射0.9%氯化钠溶液1 ml。全部大鼠于建模第15天开始，每日给药前30 min、给药后30 min进行疼痛行为学测定，包括甩尾实验、机械性痛觉敏感度测定、热痛觉敏感度测定。结果 给药7天内，机械痛阈和甩尾实验测定抗伤害痛阈结果显示，各MB组与M组给药后痛阈差异均无统计学意义；热痛阈结果显示：MB2组出现明显的热痛阈下降较M组晚（第6天vs.第5天）。结论 骨癌痛大鼠癌痛治疗时，丁丙诺啡与吗啡联合应用镇痛作用相似且可延缓吗啡的耐受发生
%K 吗啡
%K 丁丙诺啡
%K 联合用药
%K 耐受
%K 骨癌痛
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%U http://www.zlfzyj.com/CN/abstract/abstract8489.shtml