度洛西汀对多西他赛化疗所致大鼠神经病理性疼痛的影响
DOI: 10.3971/j.issn.1000-8578.2016.09.006
Keywords: A Meta-analysis,Clinical Observation of Calf Spleen Extractive Injection Combined with Docetaxel plus#br# Capecitabine Chemotherapy in Treatment for Advanced Breast Cancer Patients,Effects of Nav1.7 Expression on Neuropathic Pain Induced by Oxaliplatin,Therapeutic Effects of Docetaxel Microspheres on Peritoneal Metastatic Carcinoma,Comparison of Docetaxel-based and Oxaliplatin-based First-line Treatment for Advanced Gastric Cancer in Lauren Type,Establishment of Docetaxel Resistant Variant of Human Lung Adenocarcinoma Cell Line A549/DTX and Its Resistance Mechanism,Effi cacy and Prognostic Factors of Docetaxel or Pemetrexed as First-line Treatment for Elderly Patients with Advanced Lung Adenocarcinoma,Molecular Mechanisms of Docetaxel Resistance in Breast Cancer,Clinical Efficacy of Raltitrexed Combined with Docetaxel for Advanced Gastric Cacinoma,Clinical Curative Effects of Pemetrexed Plus Nedaplatin as First-line Treatment in#br# Patients with Advanced Lung Adenocarcinoma,Effects and Mechanism of Venlafaxine on Neuropathic Pain Induced by Oxaliplatin,Clinical Value of Molecular Subtypes for Breast Cancer Predicting Therapeutic Effect and Prognosis of Dose Dense Docetaxel Neoadjuvant Chemotherapy
Abstract:
摘要 目的 研究度洛西汀对多西他赛化疗所致大鼠神经病理性疼痛的作用。方法 24只SD雄性大鼠随机分为4组（n=6）：正常对照组、度洛西汀组、多西他赛模型组及度洛西汀治疗组。在治疗后第8天，检测大鼠的机械性痛阈、热痛阈、冷痛阈，以及L4~6脊髓背根神经节（dorsal root ganglia, DRG）P物质（substance P, SP）的释放。结果 多西他赛能够产生机械性痛觉异常（P=0.009）、热痛觉过敏（P<0.001）、冷痛觉异常（P<0.001），以及L4~6脊髓DRG的SP释放（P=0.018）。而连续8天口服度洛西汀能有效降低多西他赛导致的神经病理性疼痛，减轻机械性痛觉异常（P=0.037），热痛觉过敏（P=0.001）和冷痛觉异常（P=0.002），但并没有减少P物质的释放（P=0.653）。结论 度洛西汀可能是一种潜在的有效减轻化疗诱导神经病理性疼痛的药物
Full-Text
