%0 Journal Article
%T 度洛西汀对多西他赛化疗所致大鼠神经病理性疼痛的影响
%A 于世英
%A 彭平
%A 晁腾飞
%A 汪蕾
%A 蒋继宗
%A 邱红
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.09.006
%X 摘要 目的 研究度洛西汀对多西他赛化疗所致大鼠神经病理性疼痛的作用。方法 24只SD雄性大鼠随机分为4组（n=6）：正常对照组、度洛西汀组、多西他赛模型组及度洛西汀治疗组。在治疗后第8天，检测大鼠的机械性痛阈、热痛阈、冷痛阈，以及L4~6脊髓背根神经节（dorsal root ganglia, DRG）P物质（substance P, SP）的释放。结果 多西他赛能够产生机械性痛觉异常（P=0.009）、热痛觉过敏（P<0.001）、冷痛觉异常（P<0.001），以及L4~6脊髓DRG的SP释放（P=0.018）。而连续8天口服度洛西汀能有效降低多西他赛导致的神经病理性疼痛，减轻机械性痛觉异常（P=0.037），热痛觉过敏（P=0.001）和冷痛觉异常（P=0.002），但并没有减少P物质的释放（P=0.653）。结论 度洛西汀可能是一种潜在的有效减轻化疗诱导神经病理性疼痛的药物
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%U http://www.zlfzyj.com/CN/abstract/abstract8829.shtml