微小RNAs在良恶性胸腔积液中的研究进展
DOI: 10.3971/j.issn.1000-8578.2015.04.018
Keywords: 微小RNAs,良恶性胸腔积液,表达,Effect of RORα Overexpression on Proliferation, Migration and Invasion of Human Gastric MGC803 Cells,Correlation of ChREBP mRNA Expression and Its CpG Island Methylation in Human Hepatocellular Carcinoma,Research Progress of circRNAs in Cancer,LncRNA Colorectal Neoplasia Differentially Expressed(CRNDE) Regulated Cell Proliferation and Migration in Glioma,Identification of Gene Signature in Peripheral Blood of Breast Cancer,Replication-deficient Adenovirus Carrying hsa-microRNA-149 Inhibits Proliferation of Human Hepatocellular Carcinoma Cell Lines,Clinical Value of miRNAs in Blood or Sputum as Biomarkers for Early Screening and Diagnosis of Lung Cancer,Molecular Classification of Triple Negative Breast Cancer and Its Applications,Differential Expressions of microRNAs in Rectal Adenocarcinoma Tissues,Establishment of Hepatocellular Carcinoma Cell Line HepG2 Stably Transfected by Hepatitis B Virus X Gene and Its Effects on p53-p21 Pathway,Recombinantion,Expression and Purifi cation of Cancer Testis Antigen GAGE-1,Bioinformatics-based Analysis for microRNAs Expression Profiles between Basal-like and Luminal A Breast Cancers,Expression and Clinical Significance of CIP2A in Bladder Urothelial Cell Carcinoma,Predict Metastasis Risk of Lymph Node-negative Breast Cancer by Combination 32 Gene Expression Profiles with Clinical and Pathological Data
Abstract:
摘要 microRNAs(miRNAs）是长度为19~24 nt的非编码小RNA，可通过与其靶mRNA特异性结合导致mRNA降解或翻译抑制，从而负向调控基因表达。miRNAs参与包括细胞分化、增殖、凋亡等一系列重要细胞活动的调控。miRNAs的异常表达与人类肿瘤密切相关。miRNAs具有较强的稳定性，广泛存在人体组织、体液中。本文就miRNAs在胸腔积液中的研究进展作一综述，以期为良恶性胸腔积液的鉴别等提供新的概念及思路
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