硒蛋白S基因G-105A、G-254A位点多态性与湖南汉族人群胃癌遗传易感性的相关研究
DOI: 10.3971/j.issn.1000-8578.2015.06.011
Keywords: 2 Matched Case-control Investigation on Risk Factors of Gastric Cancer in Xianyou County,Expression of CLIC4 in Gastric Carcinoma Tissues and Its Relevance to Microsatellite Instability,Efficacy and Safety of Weekly Liposome-paclitaxel or Oxaliplatin Combined with Tegafur on Elderly Advanced Gastric Cancer,Periplocin Extracted from Cortex Periplocae(CPP) Induced Apoptosis of Gastric Cancer Cells MGC-803 Through Lysosomal Pathway,Gastric Cancer Mortality Trend and Difference Decomposition Analysis in Kunshan, Jiangsu Province, 1981-2014,Effect of Ubiquitin-like with PHD and Ring Finger Domain 1 on Invasion and Metastasis of Gastric Cancer and Related Mechanism,Effects of miR-711 on Invasion, Metastasis and Epithelial Mesenchymal Transition of Gastric Cancer Cells MGC-803,Transforming Growth Factor-β1 C-509T Polymorphism and Digestive Tract Cancer Risk: A Meta-analysis,Role of p53β Isoform in Inhibitory Effect of rmhTNF Combined with Cisplatin on Human Gastric Cancer Cell Growth,Effect of siRNA Targeting Migration-inducing Protein 7 Gene on Invasion and Migration of Human Gastric Cancer Cells MKN45,Optimization of Housekeeping Gene for Normalization of Quantitative Polymerase Chain Reaction Assay in Gastric Cancer Research
Abstract:
摘要 目的 探讨湖南汉族人群硒蛋白S（SelS）基因G-105A、G-254A位点多态性与胃癌遗传易感性的相关研究。方法 采用聚合酶链反应—限制性片断长度多态性（PCR-RFLP）方法，检测113例湖南汉族胃癌患者及111例健康对照者基因型和等位基因频率，分析胃癌患者与健康对照者G-105A、G-254A位点等位基因频率及基因型频率的差异。结果 G-105A位点GG、GA和AA基因型在胃癌组和健康对照组间分别为100.0%、0.0%、0.0%和100.0%、0.0%、0.0%；G、A等位基因频率在胃癌组和健康对照组分别为100.0%、0.0%和100.0%、0.0%，胃癌组和健康对照组基因型和等位基因频率分布无差异。G-254A位点CC、CT和TT基因型在胃癌和健康对照组间分别为50.0%、37.2%、12.8%和65.8%、28.8%、5.4%；C、T等位基因频率在胃癌组和健康对照组分别为69.0%、31.0%和80.2 %、19.8%。胃癌组和健康对照组基因型和等位基因频率分布差异有统计学意义（P＜0.05）。湖南汉族人群中携带T等位基因的个体患胃癌的风险是CC基因型个体的1.89倍（OR=1.89,95%CI:1.10～3.23）。结论 SelSG-254A位点多态性与胃癌的发病具有相关性，T等位基因可能是湖南汉族人群胃癌发病的危险因素之一；湖南汉族人群可能无G-105A这一位点的多态性分布
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