%0 Journal Article
%T 硒蛋白S基因G-105A、G-254A位点多态性与湖南汉族人群胃癌遗传易感性的相关研究
%A 卢淑华
%A 朱燕
%A 李诚城
%A 毛华杰
%A 江昊宇
%A 王晓春
%A 章迪
%A 黄玉梅
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.06.011
%X 摘要 目的 探讨湖南汉族人群硒蛋白S（SelS）基因G-105A、G-254A位点多态性与胃癌遗传易感性的相关研究。方法 采用聚合酶链反应—限制性片断长度多态性（PCR-RFLP）方法，检测113例湖南汉族胃癌患者及111例健康对照者基因型和等位基因频率，分析胃癌患者与健康对照者G-105A、G-254A位点等位基因频率及基因型频率的差异。结果 G-105A位点GG、GA和AA基因型在胃癌组和健康对照组间分别为100.0%、0.0%、0.0%和100.0%、0.0%、0.0%；G、A等位基因频率在胃癌组和健康对照组分别为100.0%、0.0%和100.0%、0.0%，胃癌组和健康对照组基因型和等位基因频率分布无差异。G-254A位点CC、CT和TT基因型在胃癌和健康对照组间分别为50.0%、37.2%、12.8%和65.8%、28.8%、5.4%；C、T等位基因频率在胃癌组和健康对照组分别为69.0%、31.0%和80.2 %、19.8%。胃癌组和健康对照组基因型和等位基因频率分布差异有统计学意义（P＜0.05）。湖南汉族人群中携带T等位基因的个体患胃癌的风险是CC基因型个体的1.89倍（OR=1.89,95%CI:1.10～3.23）。结论 SelSG-254A位点多态性与胃癌的发病具有相关性，T等位基因可能是湖南汉族人群胃癌发病的危险因素之一；湖南汉族人群可能无G-105A这一位点的多态性分布
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%U http://www.zlfzyj.com/CN/abstract/abstract8516.shtml