诱导化疗＋IMRT同期化疗与IMRT同期化疗治疗局部中晚期鼻咽癌的远期疗效比较
DOI: 10.3971/j.issn.1000-8578.2016.11.010
Keywords: 鼻咽癌,诱导化疗,同期化疗,调强放疗,远期疗效,Efficacy of IMRT Combined with Capecitabine Concurrent Chemotherapy and High Intensity Focused Ultrasound for Elderly Patients with Non-operatable Pancreatic Cancer,Correlation Between Skull Base Invasion and Bone Metastases in Locally Advanced Nasopharyngeal Carcinoma Patients,Construction of RNAi Targeting CLU Gene and Effect of CLU on Biological Function of Nasopharyngeal Cancer Cells,Risk Factors Associated with Hematologic Toxicity in Concurrent Chemoradiotherapy and IMRT for Cervical Cancer,Research Progress of Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma,Effect of 5-Azacytidine on hTERT mRNA Expression and Telomerase Activity in Human Nasopharyngeal Carcinoma Cells,Relationship Between Bladder and Rectum Volume and Its Absorbed Dose of Radical Intensity Modulated Radiotherapy on Cervical Cancer,Expression of Annexin A2 in Nasopharyngeal Carcinoma Tissues and Its Clinical Significance,Trends on Morbidity of Nasopharyngeal Carcinoma Among Residents in Pudong New Area of Shanghai, 2002-2013,Effects of High Mobility Group Box-1 Protein on Migration and Invasion Ability of Nasopharyngeal Carcinoma Cell Line C666-1 in vitro,Advances of Dose-painting Radiotherapy,Correlation of DNA Repair Gene XRCC1 Single Nucleotide Polymorphism with Sensitivity of Nasopharyngeal Carcinoma Patients to Platinum Chemotherapy,Comparison Between Concurrent Chemoradiotherapy plus Sequential Chemotherapy and Sequential Chemoradiotherapy Alone on Locally Advanced Non-small Cell Lung Cancer Patients,Expression of Specific Long Non-coding RNA in Nasopharyngeal Carcinoma and Related Significance,Cisplatin-induced Senescence and Senescence-related Gene Expression Profiles in#br# Human Nasopharyngeal Carcinoma Cells CNE2
Abstract:
摘要 目的 比较局部中晚期鼻咽癌诱导化疗+IMRT同期化疗与IMRT同期化疗的远期疗效。方法 诱导化疗+同期放化疗组（诱导组）118例，同期放化疗组（同期组）106例。诱导化疗方案为TP（多西他赛+顺铂）或PF（氟尿嘧啶+顺铂），同期化疗全部采用单药顺铂方案，全组病例均接受调强放疗。Kaplan-Meier法计算生存率，Log rank检验比较组间生存曲线。结果 诱导组与同期组5年OS、DFS、DMFS、RFS分别为83.9%和82.1%（P=0.768），86.1%和79.8%（P=0.216），89.5%和84.5%（P=0.264）, 96.4%和90.8%（P=0.114）。亚组分析显示对于T晚期（T3-4N0-1）或N晚期（T1-4N2-3）的病例，诱导化疗均未明显提高OS、DFS、DMFS、RFS。两种诱导化疗方案TP与PF比较差异也无统计学意义。诱导组的血液系统不良反应及消化道不良反应较同期组明显增加。结论 诱导化疗的使用未明显提高局部中晚期鼻咽癌的远期生存率，且血液系统、消化道等不良反应明显增加
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