%0 Journal Article
%T 诱导化疗＋IMRT同期化疗与IMRT同期化疗治疗局部中晚期鼻咽癌的远期疗效比较
%A 夏冬梅
%A 姜力
%A 张勇
%A 谢鹏
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.11.010
%X 摘要 目的 比较局部中晚期鼻咽癌诱导化疗+IMRT同期化疗与IMRT同期化疗的远期疗效。方法 诱导化疗+同期放化疗组（诱导组）118例，同期放化疗组（同期组）106例。诱导化疗方案为TP（多西他赛+顺铂）或PF（氟尿嘧啶+顺铂），同期化疗全部采用单药顺铂方案，全组病例均接受调强放疗。Kaplan-Meier法计算生存率，Log rank检验比较组间生存曲线。结果 诱导组与同期组5年OS、DFS、DMFS、RFS分别为83.9%和82.1%（P=0.768），86.1%和79.8%（P=0.216），89.5%和84.5%（P=0.264）, 96.4%和90.8%（P=0.114）。亚组分析显示对于T晚期（T3-4N0-1）或N晚期（T1-4N2-3）的病例，诱导化疗均未明显提高OS、DFS、DMFS、RFS。两种诱导化疗方案TP与PF比较差异也无统计学意义。诱导组的血液系统不良反应及消化道不良反应较同期组明显增加。结论 诱导化疗的使用未明显提高局部中晚期鼻咽癌的远期生存率，且血液系统、消化道等不良反应明显增加
%K 鼻咽癌
%K 诱导化疗
%K 同期化疗
%K 调强放疗
%K 远期疗效
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%U http://www.zlfzyj.com/CN/abstract/abstract8872.shtml