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DOI: 10.3971/j.issn.1000-8578.2015.07.014
Keywords: 28 Cases Report,Sulforaphane Suppressed Proliferation of Lung Cancer Stem Cells in vitro,MDM2 siRNA Inhibits Angiogenesis by Reducing Vascular Endothelial Growth Factor Production in Breast Cancer Cells,Characteristics of CD44 and CD24-marked Cervical Cancer Cells Subgroups,Role of Nanog in Tumorigenesis and Tumor Development,Influence of Adriamycin on Human Hepatocellular Carcinoma Cells with Different Metastatic Abilities and Expression of Cancer Stem Cell Related Genes,Complementarity Determining Region 3 Repertoire of Clonal T Cell Receptor α Chain in Patients with Micrometastasis from Breast Cancer,New Progress on Tumor-associated Macrophages in Tumor Microenvironment,Correlation of Blood Oxygen Content to HIF-1α and Microvascular Density in Breast Cancer Tissues,Difference of Self-renewal and Tumorigenicity among Different Breast Cancer Stem Cells Subpopulations
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摘要 目的 探讨乳腺浸润性导管癌组织中肿瘤干细胞标志物ALDH1、CD133的表达及其与肿瘤血管生成的关系。方法 应用免疫组织化学双染法检测120例乳腺浸润性导管癌组织中ALDH1+/CD133+ 干细胞样细胞，单染法检测血管性标记CD34、CD105及VEGF的表达情况。统计ALPH1+/CD133+干细胞样细胞与临床病理因素；CD34、CD105与VEGF的关系。结果 25.83％（31/120）的病例存在ALDH1+/CD133+干细胞样细胞，ALDH1+/CD133+干细胞样细胞与ER、VEGF的表达及MVD均相关（P＜0.05），但与年龄、肿瘤直径、PR、Her-2、组织学分级及淋巴结转移均无关（P＞0.05）。结论 乳腺浸润性导管癌组织中ALDH1+/CD133+干细胞样细胞可能通过调节VEGF的表达促进肿瘤新生血管的生成
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