%0 Journal Article
%T 乳腺浸润性导管癌组织中ALDH1+/CD133+干细胞样细胞与血管生成的关系
%A 吕新全
%A 宋一民
%A 李惠翔
%A 王英姿
%A 薛金慧
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.07.014
%X 摘要 目的 探讨乳腺浸润性导管癌组织中肿瘤干细胞标志物ALDH1、CD133的表达及其与肿瘤血管生成的关系。方法 应用免疫组织化学双染法检测120例乳腺浸润性导管癌组织中ALDH1+/CD133+ 干细胞样细胞，单染法检测血管性标记CD34、CD105及VEGF的表达情况。统计ALPH1+/CD133+干细胞样细胞与临床病理因素；CD34、CD105与VEGF的关系。结果 25.83％（31/120）的病例存在ALDH1+/CD133+干细胞样细胞，ALDH1+/CD133+干细胞样细胞与ER、VEGF的表达及MVD均相关（P＜0.05），但与年龄、肿瘤直径、PR、Her-2、组织学分级及淋巴结转移均无关（P＞0.05）。结论 乳腺浸润性导管癌组织中ALDH1+/CD133+干细胞样细胞可能通过调节VEGF的表达促进肿瘤新生血管的生成
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%U http://www.zlfzyj.com/CN/abstract/abstract8543.shtml