CYP1A1和CYP1B1基因多态性与中国妇女Ⅰ型子宫内膜癌的相关性
DOI: 10.3971/j.issn.1000-8578.2018.17.0728
Keywords: 子宫内膜癌,多态性,易感性,流行病学,细胞色素P450,Influence of GSTP-1 Genetic Variation on Prognosis of Postoperative Glioblastoma Patients Received Temozolomide Combined with Radiotherapy Regimens,Recurrence-related Factors of 46 Stage Ⅰ-Ⅱ Endometrial Carcinoma Patients,Progress on Stromal Cell-related Signaling Pathways in Endometrial Carcinoma Microenvironment,Correlation of Hypothyroidism and Endometrial Carcinoma,Progress in Anticancer Therapy-related Cardiac Diseases,Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection,Disease Characteristics of 3819 Lung Cancer Patients from 1985 to 2014 in Huangshi City of Hubei Province,Effects of siRNA Targeting YKL-40 Gene on Chemosensitivity of Endometrial Cancer HEC-1A Cells to Cisplatin,Association of RTN4 Gene Polymorphism and Haplotype with Susceptibility of Nasopharyngeal Carcinoma in Guangxi Zhuang Population,Trends on Morbidity of Colorectal Cancer Among Residents in Xining City of Qinghai Province, 2009-2014,Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility,Investigation of Dynamic Constituent Ratio Changes of Lung Cancer in Ningxia, 2000-2014,Application of Geographical Spatial Analysis in Cancer Epidemiology,Epidemiologic Investigation on Mortality Due to Esophagus Cancer in Residents in Xiamen, 2005-2014,Estradiol Activates MAPK Signaling Pathway and Its Effects on Proliferation of Endometrial Cancer Ishikawa Cells
Abstract:
摘要 目的 探讨细胞色素P450 1A1（CYP1A1）和细胞色素P450 1B1（CYP1B1）基因多态性与Ⅰ型子宫内膜癌遗传易感性与流行病学高危因素的关系。方法 采用SNPshot技术，检测103例Ⅰ型子宫内膜癌患者和100例对照人群CYP1B1、CYP1A1和NQO1基因共8个位点的多态性分布，分析其与Ⅰ型子宫内膜癌易感性及肥胖、高血压等流行病学高危因素的相关性。结果 CYP1A1基因SNP位点rs4646421基因型在两组间分布频率差异有统计学意义（P<0.05），与携带CT基因型者相比，携带CC基因型的个体罹患子宫内膜癌的风险较小（OR=0.479, 95%CI: 0.255~0.899），携带T等位基因的个体子宫内膜癌的发病风险高于C等位基因携带者（OR=1.796, 95%CI: 1.203~2.680）。与携带CC基因型相比，携带TC+TT基因型在年龄>60岁、BMI≥25、绝经延迟（超过52岁）、并发高血压的女性中Ⅰ型子宫内膜癌的发病风险增加。CYP1B1基因SNPrs1056836在两组间的分布频率差异无统计学意义（P>0.05），但发生更多的碱基胞嘧啶变异为鸟嘌呤，可能会使罹患Ⅰ型子宫内膜癌的风险增加（OR=0.604, 95%CI: 0.369~0.990）。结论 CYP1A1基因SNP位点rs4646421多态性增加了Ⅰ型子宫内膜癌的发病风险，并且与流行病学高危因素有关，有望成为Ⅰ型子宫内膜癌筛查的潜在指标
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