%0 Journal Article
%T CYP1A1和CYP1B1基因多态性与中国妇女Ⅰ型子宫内膜癌的相关性
%A 王冬
%A 舒锦
%A 陈文娟
%A 黄裕
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0728
%X 摘要 目的 探讨细胞色素P450 1A1（CYP1A1）和细胞色素P450 1B1（CYP1B1）基因多态性与Ⅰ型子宫内膜癌遗传易感性与流行病学高危因素的关系。方法 采用SNPshot技术，检测103例Ⅰ型子宫内膜癌患者和100例对照人群CYP1B1、CYP1A1和NQO1基因共8个位点的多态性分布，分析其与Ⅰ型子宫内膜癌易感性及肥胖、高血压等流行病学高危因素的相关性。结果 CYP1A1基因SNP位点rs4646421基因型在两组间分布频率差异有统计学意义（P<0.05），与携带CT基因型者相比，携带CC基因型的个体罹患子宫内膜癌的风险较小（OR=0.479, 95%CI: 0.255~0.899），携带T等位基因的个体子宫内膜癌的发病风险高于C等位基因携带者（OR=1.796, 95%CI: 1.203~2.680）。与携带CC基因型相比，携带TC+TT基因型在年龄>60岁、BMI≥25、绝经延迟（超过52岁）、并发高血压的女性中Ⅰ型子宫内膜癌的发病风险增加。CYP1B1基因SNPrs1056836在两组间的分布频率差异无统计学意义（P>0.05），但发生更多的碱基胞嘧啶变异为鸟嘌呤，可能会使罹患Ⅰ型子宫内膜癌的风险增加（OR=0.604, 95%CI: 0.369~0.990）。结论 CYP1A1基因SNP位点rs4646421多态性增加了Ⅰ型子宫内膜癌的发病风险，并且与流行病学高危因素有关，有望成为Ⅰ型子宫内膜癌筛查的潜在指标
%K 子宫内膜癌
%K 多态性
%K 易感性
%K 流行病学
%K 细胞色素P450
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%K Progress on Stromal Cell-related Signaling Pathways in Endometrial Carcinoma Microenvironment
%K Correlation of Hypothyroidism and Endometrial Carcinoma
%K Progress in Anticancer Therapy-related Cardiac Diseases
%K Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection
%K Disease Characteristics of 3819 Lung Cancer Patients from 1985 to 2014 in Huangshi City of Hubei Province
%K Effects of siRNA Targeting YKL-40 Gene on Chemosensitivity of Endometrial Cancer HEC-1A Cells to Cisplatin
%K Association of RTN4 Gene Polymorphism and Haplotype with Susceptibility of Nasopharyngeal Carcinoma in Guangxi Zhuang Population
%K Trends on Morbidity of Colorectal Cancer Among Residents in Xining City of Qinghai Province
%K 2009-2014
%K Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility
%K Investigation of Dynamic Constituent Ratio Changes of Lung Cancer in Ningxia
%K 2000-2014
%K Application of Geographical Spatial Analysis in Cancer Epidemiology
%K Epidemiologic Investigation on Mortality Due to Esophagus Cancer in Residents in Xiamen
%K 2005-2014
%K Estradiol Activates MAPK Signaling Pathway and Its Effects on Proliferation of Endometrial Cancer Ishikawa Cells
%U http://www.zlfzyj.com/CN/abstract/abstract9092.shtml