异常凝血酶原联合CEA、CA72-4和CA199在胃癌诊治中的价值
DOI: 10.3971/j.issn.1000-8578.2018.17.1007
Keywords: A Meta-analysis,Mechanism of miRNA-451 Regulating Resistance of Gastric Cancer Cells to 5-Fu Through MRP,Effect of Da Vinci Robot Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones of Gastric Cancer Patients,Effect of ANLN Gene Silencing on Invasion, Migration, Proliferation and Apoptosis of Gastric Cancer Cells,Related Factors and Risk Model Prediction of Pneumonia After ESD in Patients with Early Gastric Cancer,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Malignant Peripheral Nerve Sheath Tumor Arising from Neurofibromatosis Type 1: A Case Report and Literature Review,Advances of Exosomes in Diagnosis and Treatment of Pancreatic Cancer,Effect of FBXL20 on Proliferation, Migration and Invasion of Gastric Cancer Cells,Expression of Serum miR-1246 in Patients with Cervical Squamous Cell Carcinoma and Its Clinical Significance,Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer,Qualitative Diagnostic Value of Different Apparent Diffusion Coefficients on Metastatic Pelvic Lymph Nodes in Prostate Cancer,A Multi-center Randomized Controlled Clinical Study of Kang’ai Injection Combined with OFL Regimen on Gastric Cancer Patients,Expression and Clinical Significance of miR-181d in Serum and PDCD4 in Gastric Cancer Patients,Clinical Analysis of 120 Cases of Multiple Primary Malignant Neoplasms
Abstract:
摘要 目的 拟评估异常凝血酶原（PIVKA-Ⅱ）联合CEA、CA199和CA72-4在胃癌的诊断、治疗及复发转移监测中的应用价值。方法 化学发光法检测123例胃癌患者、80名健康对照者以及30例胃良性疾病患者血清中的PIVKA-Ⅱ水平及CEA、CA199、CA72-4水平，并对其中20例胃癌患者进行随访检测。结果 胃癌患者血清PIVKA-Ⅱ水平明显高于胃部良性疾病患者和健康对照者（均P<0.001）。ROC曲线分析，PIVKA-Ⅱ检测胃癌的临界值为32.14 U/L、敏感度为39.84%、特异性为95%，相比于CEA、CA199、CA72-4的检测，敏感度未有显著提高，特异性稍低。胃癌患者血清PIVKA-Ⅱ水平及阳性率随着肿瘤分期的升高而升高（均P<0.05）。进行有效治疗的20例进展期胃癌患者PIVKA-Ⅱ水平下降。四项组合诊断胃癌的敏感度和有效性最高。结论 PIVKA-Ⅱ联合CEA、CA199、CA72-4检测在胃癌的诊断、疗效及监测复发转移中，具有一定的临床价值
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