%0 Journal Article
%T 异常凝血酶原联合CEA、CA72-4和CA199在胃癌诊治中的价值
%A 喻晶
%A 王堃
%A 蔡晓娟
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1007
%X 摘要 目的 拟评估异常凝血酶原（PIVKA-Ⅱ）联合CEA、CA199和CA72-4在胃癌的诊断、治疗及复发转移监测中的应用价值。方法 化学发光法检测123例胃癌患者、80名健康对照者以及30例胃良性疾病患者血清中的PIVKA-Ⅱ水平及CEA、CA199、CA72-4水平，并对其中20例胃癌患者进行随访检测。结果 胃癌患者血清PIVKA-Ⅱ水平明显高于胃部良性疾病患者和健康对照者（均P<0.001）。ROC曲线分析，PIVKA-Ⅱ检测胃癌的临界值为32.14 U/L、敏感度为39.84%、特异性为95%，相比于CEA、CA199、CA72-4的检测，敏感度未有显著提高，特异性稍低。胃癌患者血清PIVKA-Ⅱ水平及阳性率随着肿瘤分期的升高而升高（均P<0.05）。进行有效治疗的20例进展期胃癌患者PIVKA-Ⅱ水平下降。四项组合诊断胃癌的敏感度和有效性最高。结论 PIVKA-Ⅱ联合CEA、CA199、CA72-4检测在胃癌的诊断、疗效及监测复发转移中，具有一定的临床价值
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%U http://www.zlfzyj.com/CN/abstract/abstract9174.shtml