核转录因子E47和LOXL2在食管鳞癌组织中的表达及其临床意义
DOI: 10.3971/j.issn.1000-8578.2018.18.0137
Keywords: 食管鳞癌,核转录因子E47,赖氨酰氧化酶样蛋白-2,上皮间质转化,CircHIPK3 Affects Malignant Phenotypes in Esophageal Squamous Cell Carcinoma by Regulating p53-Akt-Mdm2 Signaling Pathways,Curcumin Reverses Ionizing Radiation-induced Epithelial Mesenchymal Transformation of Non-small Cell Lung Cancer A549 Cells,Antitumor Efficacy and Mechanisms of Lapatinib in Combination with Cisplatin on Esophageal Squamous Cancer Cells,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Comparison of Survival Status and Related Risk Factors of Esophageal Squamous Cell Carcinoma Patients Between High- and Low-incidence Areas of ESCC,Effect and Mechanism of Metformin on Side Population Cells of Human Esophageal Squamous Cell Carcinoma,Effect of Postoperative Chemotherapy on Prognosis of Postoperative Lymph Nodepositive Thoracic Esophageal Squamous Cell Carcinoma Patients,Garcinone E Inhibits Proliferation, Migration and Invasion of Human Nasopharyngeal Carcinoma Cells,Gab2 Promotes Invasion and Metastasis of Gastric Cancer via Regulating EMT,Regulatory Effects of miR-205 on Invasion and Migration of Gastric Cancer Cells and Potential Mechanism,Sensitivity of Esophageal Squamous Carcinoma Cell Line KYSE150 to Cisplatin Can Be Improved by RNA-interfered Expression of IQGAP1,Characteristics and Influence Factors of Lymph Node Metastasis and Their Effect on Survival of Esophageal Squamous Cell Carcinoma Patients,Advances of Endoplasmic Reticulum Stress/Unfolded Protein Response Promote Tumor Invasion,Effect of Hypoxia on Epithelia-mesenchymal Transition of Prostate Cancer PC3 Cells
Abstract:
摘要 目的 探讨核转录因子E47和赖氨酰氧化酶样蛋白2（LOXL2）在食管鳞癌组织中的表达及其与临床病理特征的关系。方法 采用实时荧光定量PCR和免疫组织化学方法检测E47和LOXL2在食管鳞癌组织及癌旁正常组织中mRNA和蛋白的表达情况，并分析其与临床病理特征的关系。结果 E47和LOXL2 mRNA在食管鳞癌组织中的表达量明显高于癌旁正常组织（均P<0.05）。 E47和LOXL2蛋白在食管鳞癌组织中的阳性表达率明显高于癌旁正常组织（均P<0.05）；E47蛋白表达与浸润深度密切相关，LOXL2蛋白表达与分化程度、淋巴结转移密切相关。食管鳞癌组织中E47与LOXL2蛋白表达呈正相关关系（r=0.582, P<0.05）。结论 E47和LOXL2 mRNA和蛋白在食管鳞癌组织中高表达，并与临床病理特征相关。E47和LOXL2高表达可能参与食管鳞癌的侵袭与转移，可作为判断食管癌预后的分子标志物
Full-Text
