%0 Journal Article
%T 核转录因子E47和LOXL2在食管鳞癌组织中的表达及其临床意义
%A 侯敏杰
%A 张燕萍
%A 朱亚杰
%A 李金钰
%A 迪里胡马尔.艾海提
%A 郭琼
%A 马红
%A 马遇庆
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0137
%X 摘要 目的 探讨核转录因子E47和赖氨酰氧化酶样蛋白2（LOXL2）在食管鳞癌组织中的表达及其与临床病理特征的关系。方法 采用实时荧光定量PCR和免疫组织化学方法检测E47和LOXL2在食管鳞癌组织及癌旁正常组织中mRNA和蛋白的表达情况，并分析其与临床病理特征的关系。结果 E47和LOXL2 mRNA在食管鳞癌组织中的表达量明显高于癌旁正常组织（均P<0.05）。 E47和LOXL2蛋白在食管鳞癌组织中的阳性表达率明显高于癌旁正常组织（均P<0.05）；E47蛋白表达与浸润深度密切相关，LOXL2蛋白表达与分化程度、淋巴结转移密切相关。食管鳞癌组织中E47与LOXL2蛋白表达呈正相关关系（r=0.582, P<0.05）。结论 E47和LOXL2 mRNA和蛋白在食管鳞癌组织中高表达，并与临床病理特征相关。E47和LOXL2高表达可能参与食管鳞癌的侵袭与转移，可作为判断食管癌预后的分子标志物
%K 食管鳞癌
%K 核转录因子E47
%K 赖氨酰氧化酶样蛋白-2
%K 上皮间质转化
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%U http://www.zlfzyj.com/CN/abstract/abstract9227.shtml