大剂量粒系集落刺激因子使老年急性髓系白血病患者受益
DOI: 10.3971/j.issn.1000-8578.2018.17.1096
Keywords: Three Cases Report and Literature Review,Risk Factors for Death of Advanced Lung Cancer Patients with Lung Infection,Clinicopathological Features, Treatment and Prognosis of Invasive Breast Cancer Patients over 70 Years Old,Correlation Between States of Hepatitis B Virus Infection, Levels of Hepatitis B Surface Antigens/Antibodies and Staging, Prognosis of Colon Cancer,Leukemia with Solid Tumor: A Case Report and Literature Review,Myelogenous Blast Crisis of Chronic Myeloid Leukemia(CML-BC) with Complex Karyotype and T Lymphocyte Lymphoma/Leukemia: A Case Report and Literature Review,Mixed-phenotype Acute Leukemia Developed by Chronic Myelogenous Leukemia: A Case Report and Literature Review,Trends of Leukemia Mortality in Kunshan City, Jiangsu Province from 1993 to 2014,Effect of ΔNp63α on Leukemia Inhibitory Factor Expression in Cervical Cancer Cells and Related Mechanism,Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia,Reversion Impact of Peptide Extract from Scorpion Venom on Multidrug-resistance of Leukemia Stem Cell Line K562/A02 in vivo,NOTCH1 Down-regulates Tumor Suppressor Gene ID4 in T-cell Acute Lymphoblastic Leukemia
Abstract:
摘要 目的 探讨老年急性髓系白血病（AML）化疗期间预防性大剂量（>5 μg/kg）和标准剂量（5 μg/kg）使用G-CSF对感染、输血情况的影响。方法 回顾性对比分析82例老年AML 273个化疗周期中两组G-CSF进行支持治疗中抗生素和抗真菌药物使用情况、发热天数、发热程度、粒缺时间、输血情况等。结果 273个化疗周期中合并感染223次（81.7%），因感染中断治疗11例（13.4%）；标准剂量组中2例（2.3%）患者在诱导治疗期间死亡。亚组分析发现，大剂量组可明显缩短巩固治疗期间粒缺时间、发热天数及减少抗真菌药物的使用。结论 大剂量G-CSF可提高老年AML患者化疗期间的安全性、耐受性
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