%0 Journal Article
%T 大剂量粒系集落刺激因子使老年急性髓系白血病患者受益
%A 刘云涛
%A 孙明媛
%A 宫本法
%A 张广吉
%A 李巍
%A 王建祥
%A 秘营昌
%A 邱少伟
%A 魏述宁
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1096
%X 摘要 目的 探讨老年急性髓系白血病（AML）化疗期间预防性大剂量（>5 μg/kg）和标准剂量（5 μg/kg）使用G-CSF对感染、输血情况的影响。方法 回顾性对比分析82例老年AML 273个化疗周期中两组G-CSF进行支持治疗中抗生素和抗真菌药物使用情况、发热天数、发热程度、粒缺时间、输血情况等。结果 273个化疗周期中合并感染223次（81.7%），因感染中断治疗11例（13.4%）；标准剂量组中2例（2.3%）患者在诱导治疗期间死亡。亚组分析发现，大剂量组可明显缩短巩固治疗期间粒缺时间、发热天数及减少抗真菌药物的使用。结论 大剂量G-CSF可提高老年AML患者化疗期间的安全性、耐受性
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%U http://www.zlfzyj.com/CN/abstract/abstract9159.shtml