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-  2018 

肺腺癌中HLA-G的表达及其与患者预后的关系

DOI: 10.3971/j.issn.1000-8578.2018.17.1594

Keywords: A Meta-analysis,Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression,Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer,Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients,Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer,Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients,Clinical Treatment and Prognosis of 101 Patients with Small Cell Neuroendocrine Carcinoma of Cervix,Effect of Marital Status on Survival of Lung Cancer Patients Investigated Based on SEER Database,Clinical Characteristics and Prognosis of Primary Thyroid Lymphoma Patients

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Abstract:

摘要 目的 探讨HLA-G在肺腺癌中的表达及其与患者预后的关系。方法 使用cBioPortal数据分析工具,分析HLA-G分子在肺癌中的表达;Kaplan-Meier Plotter数据库分析HLA-G分子在肺腺癌中的表达及与预后的关系;免疫组织化学法检测HLA-G蛋白分子在223例肺腺癌组织中的表达,分析其与临床病理特征的相关性。结果 HLA-G基因的改变主要表现为扩增和错义突变,其中,扩增突变主要在肺腺癌中。 HLA-G分子的表达与肺腺癌的预后呈负相关,HLA-G高表达组患者总生存期明显短于低表达患者。结论 HLA-G分子在肺腺癌中高表达,在肺腺癌中是一种不良预后因素

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