%0 Journal Article
%T 肺腺癌中HLA-G的表达及其与患者预后的关系
%A 司加慧
%A 张攀攀
%A 张文龙
%A 杨跃
%A 马媛媛
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1594
%X 摘要 目的 探讨HLA-G在肺腺癌中的表达及其与患者预后的关系。方法 使用cBioPortal数据分析工具，分析HLA-G分子在肺癌中的表达；Kaplan-Meier Plotter数据库分析HLA-G分子在肺腺癌中的表达及与预后的关系；免疫组织化学法检测HLA-G蛋白分子在223例肺腺癌组织中的表达，分析其与临床病理特征的相关性。结果 HLA-G基因的改变主要表现为扩增和错义突变，其中，扩增突变主要在肺腺癌中。 HLA-G分子的表达与肺腺癌的预后呈负相关，HLA-G高表达组患者总生存期明显短于低表达患者。结论 HLA-G分子在肺腺癌中高表达，在肺腺癌中是一种不良预后因素
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%U http://www.zlfzyj.com/CN/abstract/abstract9211.shtml