放射性心脏损伤的研究进展
DOI: 10.3971/j.issn.1000-8578.2018.18.0893
Keywords: A Retrospective Study,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Progress on Resistance Mechanisms and Overcoming Strategies to Thirdgeneration EGFR-TKIs in Advanced Non-small Cell Lung Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies,Effect of Selective Increase of Single Dose of PTV on Prognosis of Patients with Esophageal Cancer,Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer,Research Progress on Potential Therapeutic Targets of Small Cell Lung Cancer,Research Progress of Combination Therapy of Apatinib on Tumor,Evaluation of 192Ir-Based Hypofractionated Stereotactic Ablative Brachytherapy as A Neoadjuvant Treatment for Operable Peripheral Non-small Cell Lung Cancer,Research Advances in Molecular Regulatory Mechanism of Chordoma,Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis,Influence of Different Radio-chemotherapy Modes for Incidence of Radiation Pneumonitis in Patients with Lung Cancer,Prophylactic Radiotherapy for Procedure Tract Metastases in Malignant Pleural Mesothelioma: A Meta-analysis
Abstract:
摘要 放射治疗可以提高许多恶性肿瘤患者的生存率，但辐射诱发的副作用，特别是胸部照射可能引发的心脏、血管和肺的损伤，导致组织重塑，这个复杂的过程是由大量相互作用的分子信号组成，包括细胞因子、趋化因子和生长因子。而炎性反应、内皮细胞功能障碍、血栓形成、器官功能障碍以及最终的心脏衰竭是一种病理实体“放射性心脏损伤”，与纵隔淋巴瘤、乳腺癌、肺癌和食管癌等放射治疗有关，是胸部肿瘤放疗后发病率和死亡率的主要来源之一。而长期潜伏期是RIHD不被广泛研究的原因，但随着肿瘤患者生存时间延长，放疗所致的迟发性心脏损伤的问题越发突出。除了老年患者，年轻患者治疗后RIHD发生率也在逐渐增高，因此RIHD越来越受到关注和重视。本文将对放射性心脏损伤的类型、发病机制、影响因素的相关研究进行综述
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