%0 Journal Article
%T 放射性心脏损伤的研究进展
%A 刘志飞
%A 王颖杰
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0893
%X 摘要 放射治疗可以提高许多恶性肿瘤患者的生存率，但辐射诱发的副作用，特别是胸部照射可能引发的心脏、血管和肺的损伤，导致组织重塑，这个复杂的过程是由大量相互作用的分子信号组成，包括细胞因子、趋化因子和生长因子。而炎性反应、内皮细胞功能障碍、血栓形成、器官功能障碍以及最终的心脏衰竭是一种病理实体“放射性心脏损伤”，与纵隔淋巴瘤、乳腺癌、肺癌和食管癌等放射治疗有关，是胸部肿瘤放疗后发病率和死亡率的主要来源之一。而长期潜伏期是RIHD不被广泛研究的原因，但随着肿瘤患者生存时间延长，放疗所致的迟发性心脏损伤的问题越发突出。除了老年患者，年轻患者治疗后RIHD发生率也在逐渐增高，因此RIHD越来越受到关注和重视。本文将对放射性心脏损伤的类型、发病机制、影响因素的相关研究进行综述
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%U http://www.zlfzyj.com/CN/abstract/abstract9268.shtml