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-  2018 

肿瘤的光遗传学治疗

DOI: 10.3971/j.issn.1000-8578.2018.18.0642

Keywords: A Scientometric Analysis,Efficacy of Definitive External-beam Radiotherapy Versus Radical Prostatectomy on Clinically Localized High-risk Prostate Cancer Patients: A Retrospective Study,A Case Report of Four Primary Malignant Tumors,Oncolytic Adenovirus RCA-TERT-Ad35 Carrying Human Telomerase Reverse Transcriptase Promoter Targets Breast Cancer Stem Cells,Research Progress of Intestinal Microbiota and Immune Checkpoint Inhibitors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,A Comprehensive Review of Androgen Deprivation Therapy and Immunotherapy on Prostate Cancer,Antitumor and Apoptosis Induction Effects of Gold Nanorods-mediated Near-infrared Photothermal Therapy on Gastric Cancer SGC-7901 Cells in vitro,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy

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Abstract:

摘要 光遗传学技术应用遗传学和光的方法刺激和控制生物组织中特定细胞的功能。自从2005年报道用光照射视蛋白精准控制神经活性以来,光遗传学在肿瘤治疗中的应用初见端倪,其作用机制包括操纵神经元活动、解除免疫抑制、改变细胞内外电压、控制细胞力、调控信号转导、遗传和表观遗传调节以及筛选抗肿瘤药物。未来将通过光刺激改变肿瘤行为,肿瘤光遗传学治疗前途光明

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