微小RNA-181d在食管鳞状细胞癌中的表达及其临床意义
DOI: 10.3971/j.issn.1000-8578.2018.18.0716
Keywords: A Meta-analysis,Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression,Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer,Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients,Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer,Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients,Clinical Treatment and Prognosis of 101 Patients with Small Cell Neuroendocrine Carcinoma of Cervix,Effect of Marital Status on Survival of Lung Cancer Patients Investigated Based on SEER Database,Clinical Characteristics and Prognosis of Primary Thyroid Lymphoma Patients,Prognostic Factors and Comprehensive Treatment of 95 Synovial Sarcoma Patients,Efficacy and Prognostic Factors of Docetaxel Combined with ADT on Metastatic Hormone-sensitive Prostate Cancer Patients
Abstract:
摘要 目的 探讨miR-181d在食管鳞状细胞癌组织中的表达，并分析其临床意义。方法 应用反转录实时荧光定量PCR（reverse transcription quantitative real-time PCR, RT-qPCR）技术检测37例食管鳞状细胞癌癌组织及癌旁组织中miR-181d的表达，分析miR-181d表达与肿瘤临床病理特征的相关性。结果 miR-181d在89.2%（33/37）的食管鳞状细胞癌组织中表达水平显著高于对应癌旁组织（P<0.01）；miR-181d表达水平与性别、年龄、浸润深度、淋巴结转移、组织学分级、肿瘤部位均无明显相关性(P>0.05)， 但与TNM分期显著相关（P<0.05）。Kaplan-Meier生存分析显示，miR-181d高表达组总生存率和无病生存率明显低于低表达组（P<0.05）。结论 miR-181d在食管鳞状细胞癌组织中的表达与肿瘤的TNM分期及预后相关，miR-181d可能作为潜在预测指标评估食管鳞状细胞癌患者的预后
Full-Text
