%0 Journal Article
%T 微小RNA-181d在食管鳞状细胞癌中的表达及其临床意义
%A 展翔
%A 崔渊博
%A 曹巍
%A 曹新广
%A 李学民
%A 赵瑞华
%A 韩鹏黎
%A 龚芬芬
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0716
%X 摘要 目的 探讨miR-181d在食管鳞状细胞癌组织中的表达，并分析其临床意义。方法 应用反转录实时荧光定量PCR（reverse transcription quantitative real-time PCR, RT-qPCR）技术检测37例食管鳞状细胞癌癌组织及癌旁组织中miR-181d的表达，分析miR-181d表达与肿瘤临床病理特征的相关性。结果 miR-181d在89.2%（33/37）的食管鳞状细胞癌组织中表达水平显著高于对应癌旁组织（P<0.01）；miR-181d表达水平与性别、年龄、浸润深度、淋巴结转移、组织学分级、肿瘤部位均无明显相关性(P>0.05)， 但与TNM分期显著相关（P<0.05）。Kaplan-Meier生存分析显示，miR-181d高表达组总生存率和无病生存率明显低于低表达组（P<0.05）。结论 miR-181d在食管鳞状细胞癌组织中的表达与肿瘤的TNM分期及预后相关，miR-181d可能作为潜在预测指标评估食管鳞状细胞癌患者的预后
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%U http://www.zlfzyj.com/CN/abstract/abstract9295.shtml