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DOI: 10.3971/j.issn.1000-8578.2015.08.018
Keywords: 肿瘤相关成纤维细胞,结直肠癌 肿瘤转移,上皮间质转化,血管生成,Effect of Down-regulating KLF8 Expression by siRNA on EMT in Nasopharyngeal Carcinoma Cells,Effect of Jinlong Capsule on Vasculogenic Mimicry and Mig-7 of Colon Cancer,Effect of CGB5 on Human Epithelial Ovarian Cancer Cell Line OVCAR-3 in Vasculogenic Mimicry Formation,Experiment of Different Administration Sequences of Apatinib and Paclitaxel on Lung Cancer,Correlation Between Epithelial-mesenchymal Transition and Sensitivity to EGFR Targeted Monoclonal Antibody in Triple Negative Breast Cancer Cells,Effects of miR-711 on Invasion, Metastasis and Epithelial Mesenchymal Transition of Gastric Cancer Cells MGC-803,Different Administration Ways of Endostar Combined with TP Regimen on Advanced Ovarian Cancer Patients,Role of Hepatocyte Growth Factor Receptor c-met Regulating Epithelial-mesenchymal Transition in Metastasis of Colorectal Cancer,Inhibitory Effect of Silencing PCAF Gene on Growth and Angiogenesis of Human Adrenocortical Carcinoma Xenograft in Nude Mice,Nrf2-mediated Multidrug Resistance after Epithelial-mesenchymal Transition in Lung Cancer Cells,Effect of Transcription Factor Snail on Invasion and Migration of Esophageal Carcinoma Cell Line Eca-109,Progress in Relationship between Sox2 Gene and Cancer,Effects of Bcl-2 Interference on Esophageal Cancer Cell Ec9706 Vasculogenic Mimicry in Hypoxic Microenvironment,Contribution of Epithelial-mesenchymal Transition to Vasculogenic Mimicry,Effects of Melittin on Adherence,Migration,Tube Formation and VEGFR2 Phosphorylation of EPCs
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摘要 肿瘤相关成纤维细胞（CAFs）是间质的主要细胞成分，在结直肠癌（colorectal cancer,CRC）的发生发展中发挥重要作用。CAFs通过细胞与细胞间的直接接触以及旁分泌的方式分泌各种细胞因子、生长因子和趋化因子，通过不同的信号通路促进CRC的发生、生长以及血管生成、侵袭和转移。CAFs还为CRC的早期诊断和治疗提供新的标记和新的靶点，为CRC的综合治疗提供新的思路。本文主要就近年来CAFs在结直肠癌发生发展以及诊治中作用的研究进展作一综述
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