%0 Journal Article
%T 肿瘤相关成纤维细胞在结直肠癌发生发展中的作用研究进展
%A 谢中意
%A 郑淑芳
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.08.018
%X 摘要 肿瘤相关成纤维细胞（CAFs）是间质的主要细胞成分，在结直肠癌（colorectal cancer,CRC）的发生发展中发挥重要作用。CAFs通过细胞与细胞间的直接接触以及旁分泌的方式分泌各种细胞因子、生长因子和趋化因子，通过不同的信号通路促进CRC的发生、生长以及血管生成、侵袭和转移。CAFs还为CRC的早期诊断和治疗提供新的标记和新的靶点，为CRC的综合治疗提供新的思路。本文主要就近年来CAFs在结直肠癌发生发展以及诊治中作用的研究进展作一综述
%K 肿瘤相关成纤维细胞
%K 结直肠癌 肿瘤转移
%K 上皮间质转化
%K 血管生成
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%U http://www.zlfzyj.com/CN/abstract/abstract8571.shtml