免疫组织化学标志物在髓母细胞瘤分子分型中的研究进展
DOI: 10.3971/j.issn.1000-8578.2018.17.1186
Keywords: A Case Report and Literature Review,Correlation of Hypothyroidism and Endometrial Carcinoma,Breast Metastasis of Primary Pulmonary Adenocarcinoma: A Report of Two Cases and Literature Review,Correlation of Genotypes with Clinicopathological and Prognostic Characteristics of Breast Cancer Patients,HER2 (++) Amplification in Breast Cancer Detected by Fluorescence in Situ Hybridization and Its Correlation with Clinicopathological Features,Review of Molecular Subtyping of Ovarian Cancer and Its Clinical Application,Micronodular Thymoma with Lymphoid Stroma: A Case Report,Napsin A, TTF1 and SPA Protein Expressions and Their Correlation with EGFR Gene Mutations in Primary Lung Adenocarcinoma,Expression of Ubiquilin1 Protein in Breast Cancer Tissues and Its Prognostic Significance,Expressions of PLAC8 Protein in Nasopharyngeal Carcinoma Cells and Related Clinical Significance,Expression of Podocalyxin in Breast Cancer Tissues,Methylation Status of MGMT Gene Promoter in Patients with Adenocarcinoma of Esophagogastric Junction and Its Relationship with Prognosis,Expression and Correlation of Id-1, MMP-9 and LMVD in Colorectal Adenocarcinoma Tissues,Molecular Classification of Common Solid Cancers
Abstract:
摘要 髓母细胞瘤是好发于小脑的恶性胚胎性侵袭性肿瘤，常见于儿童。2016年WHO根据基因组遗传学特征将髓母细胞瘤分为四种分子亚型。本文综述了常见的免疫组织化学标志物在分子分型中的应用情况，发现β-catenin和GAB1分别作为WNT型和SHH型的特征性标志物，具有很高的特异性和敏感度，YAP1和filamin A虽然缺乏特异性，但主要在WNT型和SHH型中表达，在Group3型和Group4型不表达或微弱表达，其他的免疫组织化学标志物特异性和敏感度都不高，没有一个免疫组织化学标志物能准确区分Group3型和Group4型。实际工作中综合上述免疫组织化学标志物组合判断可能会得到更好的结果
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