放射性核素标记Exendin-4类似物用于胰岛素瘤显像的研究进展
DOI: 10.3971/j.issn.1000-8578.2015.04.020
Keywords: 放射性核素,胰高血糖素样肽-1受体,Exendin-4,放射性核素显像,Clinical Application of 99Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer,Study of Value of 18F-FDG SPECT/CT in Evaluation of Treatment Response in Gastric Cancer,Clinical Study of All-trans-retinoic Acid in Redifferentiation Therapy for Thyroid Cancer,Inhibiting Effect of 125I-coupled Vascular Endothel ial Growth Factor ( VEGF) Antisense Oligonucleotides on Expression of VEGF in Bladder Cancer Cells,A study on pain relief of malignant bone metastasis with ~(89)Sr radionuclide therapy,Sixty-two cases of lung cancer with bone metastasis,Value of Diagosis with Radionuclide (99mTC-MDP)Bone Imaging A Report of 51 cases
Abstract:
摘要 胰岛素瘤是常见的胰腺内分泌肿瘤，常规方法难以检测。核素显像如单光子断层扫描（SPECT）和正电子断层扫描（PET）具有无创、敏感度高、特异性好等优势，为胰岛素瘤的诊断提供了新技术。胰高血糖素样肽-1受体（GLP-1R）在胰岛素瘤中高表达，是潜在的肿瘤靶点。Exendin-4作为GLP-1R激动剂，可与受体特异性结合。本文介绍放射性核素标记GLP-1R激动剂（Exendin-4）类似物的进展及在胰岛素瘤显像研究中的应用
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