%0 Journal Article %T 放射性核素标记Exendin-4类似物用于胰岛素瘤显像的研究进展 %A 杨敏 %A 罗世能 %A 许清 %J 肿瘤防治研究 %D 2015 %R 10.3971/j.issn.1000-8578.2015.04.020 %X 摘要 胰岛素瘤是常见的胰腺内分泌肿瘤,常规方法难以检测。核素显像如单光子断层扫描(SPECT)和正电子断层扫描(PET)具有无创、敏感度高、特异性好等优势,为胰岛素瘤的诊断提供了新技术。胰高血糖素样肽-1受体(GLP-1R)在胰岛素瘤中高表达,是潜在的肿瘤靶点。Exendin-4作为GLP-1R激动剂,可与受体特异性结合。本文介绍放射性核素标记GLP-1R激动剂(Exendin-4)类似物的进展及在胰岛素瘤显像研究中的应用 %K 放射性核素 %K 胰高血糖素样肽-1受体 %K Exendin-4 %K 放射性核素显像 %K Clinical Application of 99Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer %K Study of Value of 18F-FDG SPECT/CT in Evaluation of Treatment Response in Gastric Cancer %K Clinical Study of All-trans-retinoic Acid in Redifferentiation Therapy for Thyroid Cancer %K Inhibiting Effect of 125I-coupled Vascular Endothel ial Growth Factor ( VEGF) Antisense Oligonucleotides on Expression of VEGF in Bladder Cancer Cells %K A study on pain relief of malignant bone metastasis with ~(89)Sr radionuclide therapy %K Sixty-two cases of lung cancer with bone metastasis %K Value of Diagosis with Radionuclide (99mTC-MDP)Bone Imaging A Report of 51 cases %U http://www.zlfzyj.com/CN/abstract/abstract8476.shtml