过继性免疫治疗对非小细胞肺癌患者外周血T细胞亚群的影响
DOI: 10.3971/j.issn.1000-8578.2015.04.006
Keywords: A Meta-analysis,NSCLC的疫苗治疗研究进展,Advances of FGF/FGFR Signaling Pathway in Targeted Therapy for Squamous Cell Lung Cancer,Effect of Vascular Endothelial Cadherin on Invasion and Metastasis of Non-small Cell Lung Cancer Cells and Related Mechanism,Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer,Prognosis of Clinical Stage ⅢA(N2) Non-small Cell Lung Cancer Patients Received Radiotherapy,Quality Assessment of Reports of Randomized Controlled Trials Published in Chinese in Field of Non-small Cell Lung Cancer in China,Review of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Adjuvant Treatment of Non-small Cell Lung Cancer,Evaluation of Ligand-targeted PCR Method in Detecting Tumor Cell Levels in Pleural Effusion of Patients with Non-small Cell Lung Cancer,Association of Cytochrome P450 2E1-1239G>C Genetic Variation with Prognosis of Metastatic Non-small Cell Lung Cancer Patients,Prognostic Value of Serum CEA, CA125 and Cyfra21-1 in Patients with Advanced Nonsmall Cell Lung Cancer,Ionizing Radiation Overcomes Gefitinib Resistance of Non-small Cell Lung Cancer Cell Line H1975 in vitro,HOXB7 Regulates Proliferation of Non-small Cell Lung Cancer Cell A549
Abstract:
摘要 目的 研究细胞因子诱导的杀伤（cytokine-induced killer，CIK）细胞治疗对非小细胞肺癌（non-small cell lung cancer，NSCLC）患者外周血T细胞亚群及一般情况的影响。方法 采集非小细胞肺癌患者外周血，常规方法体外扩增CIK细胞，分三次回输患者体内，流式细胞仪检测非小细胞肺癌患者治疗前与治疗3次后T细胞亚群的变化，分析其与健康对照组相比外周血T细胞亚群的差异，并观察CIK细胞治疗前后患者一般情况变化。结果 与对照组相比，NSCLC患者外周血中CD3+ T 细胞比例、CD3+CD4+T细胞比例、CD4+/CD8+ 比值显著下降（P<0.05），CD3+CD8+ T细胞比例显著升高（P<0.05）。CIK细胞治疗后与治疗前，CD3+ T 细胞比例、CD3+CD4+ T细胞比例、CD4+/CD8+ T细胞比值显著升高（P<0.05），CD3+CD8+ T细胞比例显著降低（P<0.05）。CIK细胞治疗后与对照组相比，CD3+ T 细胞比例、CD4+/CD8+T细胞比值显著下降（P<0.05）。CD3+CD4+ T细胞比例、CD3+CD8+ T细胞比例升高，但差异无统计学意义（P>0.05）。CIK细胞治疗前Tregs较对照组显著升高（P<0.05）。CIK细胞治疗后与治疗前相比，Tregs比例显著下降（P<0.05）。结论 CIK细胞输注治疗可以增强NSCLC患者的免疫功能，并改善患者的一般情况，提高生活质量，且未见明显不良反应
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