%0 Journal Article
%T 过继性免疫治疗对非小细胞肺癌患者外周血T细胞亚群的影响
%A 刘丽华
%A 吕微
%A 段玉青
%A 王佳丽
%A 王婷婷
%A 王郁
%A 王雪晓
%A 贾云泷
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.04.006
%X 摘要 目的 研究细胞因子诱导的杀伤（cytokine-induced killer，CIK）细胞治疗对非小细胞肺癌（non-small cell lung cancer，NSCLC）患者外周血T细胞亚群及一般情况的影响。方法 采集非小细胞肺癌患者外周血，常规方法体外扩增CIK细胞，分三次回输患者体内，流式细胞仪检测非小细胞肺癌患者治疗前与治疗3次后T细胞亚群的变化，分析其与健康对照组相比外周血T细胞亚群的差异，并观察CIK细胞治疗前后患者一般情况变化。结果 与对照组相比，NSCLC患者外周血中CD3+ T 细胞比例、CD3+CD4+T细胞比例、CD4+/CD8+ 比值显著下降（P<0.05），CD3+CD8+ T细胞比例显著升高（P<0.05）。CIK细胞治疗后与治疗前，CD3+ T 细胞比例、CD3+CD4+ T细胞比例、CD4+/CD8+ T细胞比值显著升高（P<0.05），CD3+CD8+ T细胞比例显著降低（P<0.05）。CIK细胞治疗后与对照组相比，CD3+ T 细胞比例、CD4+/CD8+T细胞比值显著下降（P<0.05）。CD3+CD4+ T细胞比例、CD3+CD8+ T细胞比例升高，但差异无统计学意义（P>0.05）。CIK细胞治疗前Tregs较对照组显著升高（P<0.05）。CIK细胞治疗后与治疗前相比，Tregs比例显著下降（P<0.05）。结论 CIK细胞输注治疗可以增强NSCLC患者的免疫功能，并改善患者的一般情况，提高生活质量，且未见明显不良反应
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%U http://www.zlfzyj.com/CN/abstract/abstract8462.shtml