重视肿瘤生酮治疗的研究
DOI: 10.3971/j.issn.1000-8578.2018.18.0233
Keywords: A Scientometric Analysis,A Case Report of Four Primary Malignant Tumors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Progress of Stimulation Response Strategy Based on Nanomaterials in Tumor Therapy,Advances in Molecular Mechanisms of Early Bone Metastasis,Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm,Advances of Ribonucleotide Reductase Inhibitors on Cancer
Abstract:
摘要 肿瘤细胞Warburg效应为肿瘤生酮治疗奠定了坚实的理论基础，大量研究发现生酮疗法是肿瘤治疗的一个有效手段，生酮治疗可以直接抑制肿瘤生长、增强放化疗效果、提高生活质量、延长生存时间；既可以独立使用，也可以与肿瘤治疗其他方法联合。但是不同肿瘤对生酮治疗反应差异显著，机制不明。肿瘤生酮治疗目前以细胞株及其荷瘤动物研究较多，临床上以病例报告为主，缺乏设计严谨的对照研究。为了更好地推动肿瘤治疗的进步与发展，改善我国肿瘤治疗现状，笔者呼吁高度重视生酮疗法等代谢调节治疗，加快转化医学研究，加强临床随机对照研究，探讨生酮治疗疗效差异的原因及其机制，寻找新的、能够指导生酮饮食（ketogenic diet, KD）治疗的分子标志物，为精准筛选生酮治疗对象提供分子标志、建立预测肿瘤生酮治疗敏感度的分子诊断方法，发掘提高肿瘤生酮治疗疗效的干预靶点，从而进一步提高肿瘤治疗效果
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