%0 Journal Article
%T 重视肿瘤生酮治疗的研究
%A 石汉平
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0233
%X 摘要 肿瘤细胞Warburg效应为肿瘤生酮治疗奠定了坚实的理论基础，大量研究发现生酮疗法是肿瘤治疗的一个有效手段，生酮治疗可以直接抑制肿瘤生长、增强放化疗效果、提高生活质量、延长生存时间；既可以独立使用，也可以与肿瘤治疗其他方法联合。但是不同肿瘤对生酮治疗反应差异显著，机制不明。肿瘤生酮治疗目前以细胞株及其荷瘤动物研究较多，临床上以病例报告为主，缺乏设计严谨的对照研究。为了更好地推动肿瘤治疗的进步与发展，改善我国肿瘤治疗现状，笔者呼吁高度重视生酮疗法等代谢调节治疗，加快转化医学研究，加强临床随机对照研究，探讨生酮治疗疗效差异的原因及其机制，寻找新的、能够指导生酮饮食（ketogenic diet, KD）治疗的分子标志物，为精准筛选生酮治疗对象提供分子标志、建立预测肿瘤生酮治疗敏感度的分子诊断方法，发掘提高肿瘤生酮治疗疗效的干预靶点，从而进一步提高肿瘤治疗效果
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%U http://www.zlfzyj.com/CN/abstract/abstract9132.shtml