miRNA相关SNPs与肺癌遗传易感性关系的研究进展
DOI: 10.3971/j.issn.1000-8578.2016.12.017
Keywords: Twelve Cases Report and Literature Review ,Mechanism of GSK-3β and β-catenin Expression Localization Mediating Cisplatinresistance of Lung Adenocarcinoma ,Progresses of MicroRNA-135 in Tumors ,Correlation of DNA Repair Gene XRCC1 Single Nucleotide Polymorphism with Sensitivity of Nasopharyngeal Carcinoma Patients to Platinum Chemotherapy ,Cancer-related Fatigue in Advanced Lung Cancer Patients and Its Relationship with Inflammatory Cytokine in Serum ,Association of Selenoprotein S G-105A , G-254A Polymorphisms with Genetic Susceptibility to Gastric Cancer in Hu’nan Han Population ,Progress on Functional Investigation of 3’UTR SNPs in MicroRNA Targeting Genes Associated with Lung Cancer ,Relationship of TLR3 and TLR4 Gene Polymorphism with Susceptibility of EBVassociated Gastric Carcinoma ,Relationship of Clinical Characteristics and EGFR , K-RAS Mutation in Lung Adenocarcinoma Patients with Predominant Ground-glass Opacity ,RFT2 Functional SNP Influences Hereditary Susceptibility to Esophageal Squamous Cell#br# Carcinoma ,VEGF Gene Promoter Region-460 T/C Single Nucleotide Polymorphisms and#br# Nasopharyngeal Carcinoma Susceptibility in Guangxi Population ,Effects and Mechanism of Gefitinib on Radiosensitivity of Non-small Cell Lung Cancer Cell Lines A549 and H1975
Abstract:
摘要 肺癌是世界最常见的癌症，已成为癌症死亡的主要原因。microRNAs（miRNAs）是一类高度保守、内源性非蛋白编码、长度约21~24核苷酸的小分子单链RNA，在基因调控中扮演着重要的角色。miRNA相关单核苷酸多态性（miRNA-related single nucleotide polymorphisms或miR-SNPs）主要包括miRNA基因SNPs、生物合成通路相关基因SNPs和miRNA靶基因中的SNPs，可通过影响miRNA的成熟过程、表达水平及与靶mRNA的识别结合等，使miRNA调控网络发生异常，从而参与肿瘤的发生发展。本文对miRNA相关SNPs与肺癌遗传易感性关系的研究进展进行综述，旨在为肺癌等恶性肿瘤的预防和控制提供参考
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