%0 Journal Article
%T miRNA相关SNPs与肺癌遗传易感性关系的研究进展
%A 刘志强
%A 蔡琳
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.12.017
%X 摘要 肺癌是世界最常见的癌症，已成为癌症死亡的主要原因。microRNAs（miRNAs）是一类高度保守、内源性非蛋白编码、长度约21~24核苷酸的小分子单链RNA，在基因调控中扮演着重要的角色。miRNA相关单核苷酸多态性（miRNA-related single nucleotide polymorphisms或miR-SNPs）主要包括miRNA基因SNPs、生物合成通路相关基因SNPs和miRNA靶基因中的SNPs，可通过影响miRNA的成熟过程、表达水平及与靶mRNA的识别结合等，使miRNA调控网络发生异常，从而参与肿瘤的发生发展。本文对miRNA相关SNPs与肺癌遗传易感性关系的研究进展进行综述，旨在为肺癌等恶性肿瘤的预防和控制提供参考
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%U http://www.zlfzyj.com/CN/abstract/abstract8899.shtml