胃腺癌组织中LRIG1蛋白的表达及意义
DOI: 10.3971/j.issn.1000-8578.2016.06.011
Keywords: A Meta-analysis,Relationship of Tumor Location and Other Clinicopathological Features with Differentiated Thyroid Cancer with Lymph Node Metastasis,Diagnostic Value of MRI in Detection of Small Lymph Node Metastasis and Its Effects on Radiotherapy Target Volume Design in Cervical Cancer Patients,Relative Factors and Surgical Treatment of Neck Lymph Node Metastasis of cN0 Tongue Cancer,Changes of Five-year Survival Rates in Patients with Esophageal Squamous Cell#br# Carcinoma from 1973 to 2005,Comparative Analysis of Clinicopathological Changes in Esophageal Cancer Patients#br# with Ultra-long and Short-term Survival,Impact of Lymph Node Metastasis and Relevant Risk Factors on Survival of Patients#br# with Esophageal Carcinoma from High- and low-incidence Areas,Analysis of Gastrin-releasng peptide(GRP) and Its Receptor in Forecasting Metastasis of Small Cell Lung Cancer,Clinical Significance of microRNA-93 Expression in Gastric Tumor,Serum VEGF-C Combined with CA125 Assay for Detecting Lymph Node Metastasis of Ovarian Cancer,Analysis of Therapeutic Effect and Prognosis of Radiotherapy for Patients with Esophageal Carcinoma with Supraclavicular Lymph Node Metastasis,Diagnostic Value of Serum Squamous Cell Carcinoma Antigen on Lymphatic Metastasis in Cervical Cancer:a Meta analysis
Abstract:
摘要 目的 探讨富亮氨酸重复序列免疫球蛋白样结构域1（LRIG1）在人体胃腺癌组织中的表达及其与临床病理参数的关系。方法 采用免疫组织化学EnVision二步法检测LRIG1蛋白在116例胃腺癌及其相应癌旁正常胃组织中的表达情况，并分析其表达与临床病理参数的关系。结果 LRIG1在胃腺癌组织中的阳性表达率（63.8%，74/116）低于癌旁正常胃组织（81.9%，95/116），差异具有统计学意义（P<0.05）。LRIG1蛋白的表达与肿瘤的分化程度、浸润深度、淋巴结转移、远处转移及TNM分期密切相关（P<0.05），而与患者年龄、性别及肿瘤大小无关（P>0.05）。结论 LRIG1在胃腺癌组织中的表达较相应癌旁正常胃组织低，而且随着肿瘤恶性程度的增加LRIG1蛋白的表达逐渐降低，可能作为抑癌基因参与了胃腺癌的发生、发展
Full-Text
